New Horizons in Life Sciences

Estrogen is a key hormone in both genders, though predominant in the females. When aromatase enzyme (cytochromes P450) acts on androgen (C19), estrogen (C18) is formed. Estrogen is critical player in glucose homeostasis, immune defense, bone health, cardiovascular health, fertility, and neural functions. Estrogen imbalance can cause pathologies ranging from infectious, autoimmune, metabolic to degenerative.  Aging depletes estrogen level, causing bone, muscle, neural degeneration. The increasing exposure to inflammatory agents is fueling ‘estrogen dominance’. The encounter to excess estrogen mimics or xeno-estrogens, is inducing the overexpression of estrogen receptors (ERa and ERß). This overabundance of ER receptors is causing metabolic, autoimmune diseases, and cancers. The diseases like polycystic ovary syndrome (PCOS), endometriosis, breast cancer, ovary cancer, and gynecomastia, osteoporosis are direct result of estrogen imbalance. Apart from that, gastric cancer, pituitary cance

Polycystic ovary syndrome (PCOS) is an inflammatory disease, originated from lifestyle abuses. Its an endocrine disorder characterized by amenorrhea, anovulation, hirsutism, hyperandrogenism, and hyperprolactinemia. PCOS can cause infertility, and its co-morbidities include insulin resistance, obesity, cardiovascular problems, among other health issues. As a result of PCOS, ovulation is impaired; fertilization, and conception is affected; even if implantation occurs, abortion and still birth risks increases. High blood pressure (eclampsia) and the small-for-gestational-age babies (IUGR) can occur. PCOS can cause several pregnancy-related complications as gestational diabetes. So, basically every step of pregnancy is jeopardized by PCOS. It is understandable as a critical and prolonged adaptation like pregnancy, requires the hormonal circuitry to be in good shape. PCOS is teh other name of hormonal imbalance. So, pregnancy becomes unpredictable, and dangerous. Interventions like oral co